ChemiSCREEN™ B2 Bradykinin Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ B2 Bradykinin Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. bradykinin) based activation of BDKRB2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses BDKRB2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of BDKRB2 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Bradykinin

Sub Family:

Class A

Protein Name:

B2

Protein Aliases:

BK-2 receptor

Accession Number:

M88714

UniProt Number:

P30411

Gene Name:

BDKRB2

Gene ID:

624

Gene Aliases:

BK-2|BKR2

Target Species:

Human

Cell Background:

Chem-1