ChemiBRITE LH Glycoprotein Hormone Receptor Stable Cell Line

Background Information:

The ChemiBRITE LH Glycoprotein Hormone Receptor cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. luteinizing hormone, hCG) based activation of LHCGR GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LHCGR alongside exogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. ChemiBRITE cells also express a clytin variant, allowing for luminescent as well as fluorescent signal detection. Upon activation of LHCGR , the resulting calcium activity can be assayed in either detection mode.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Glycoprotein Hormone

Sub Family:

Class A

Protein Name:

LH

Protein Aliases:

Luteinizing hormone receptor|LHR|LSH-R

Accession Number:

BC156303

UniProt Number:

P22888

Gene Name:

LHCGR

Gene ID:

3973

Gene Aliases:

LHR|LCGR|LGR2|ULG5|LGR2|LHRHR

Target Species:

Human

Cell Background:

HEK293