ChaK1, active

Background Information:

CHAK1 is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. GenBank AY032950.1

Target Class:

Kinase

Family:

Alpha kinase

Sub Family:

Atypical

Protein Name:

CHAK1

Accession Number:

AY032950.1

UniProt Number:

Q96QT4

Gene Name:

TRPM7

Gene ID:

54822

Gene Aliases:

CHAK1|LTRPC7|TRP-PLIK

Target Species:

Human