Casein Kinase 2, active

Background Information:

Casein kinase 2 (CK2) is a serine/threonine protein kinase that is ubiquitously expressed in eukaryotic cells. CK2 is a heterotetrameric enzyme composed of two catalytic subunits (α and/or α') and two regulatory subunits (β). The α and α' subunits have high sequence identity and are functionally interchangeable. CK2 plays a role in many cellular processes, including cell growth, proliferation, differentiation, and apoptosis. It has been shown to regulate the activity of various transcription factors, kinases, and phosphatases. CK2 is also involved in the regulation of ion channels, membrane transporters, and the cytoskeleton.
Overexpression of CK2 has been observed in many types of cancer, and has been linked to the regulation of oncogenes and tumor suppressor genes. CK2 has also been implicated in the regulation of viral infections, and is known to be involved in the replication of several viruses, including hepatitis C virus, HIV, and human papillomavirus.

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

CK2alpha1

Accession Number:

NM_001320; NM_001895.3; NM_177559.2; NM_177560.2

UniProt Number:

P68400

Gene Name:

CSNK2A1

Gene ID:

1457

Gene Aliases:

CK2A1

Target Species:

Human