Biological Information

Background Information:

The cAMP Hunter™ Rat GLP1R Gs cell line (CHO-K1) is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. exendin-4) based activation of Rat GLP1R GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type Rat GLP1R , a naturally Gs coupled GPCR. Upon activation of Rat GLP1R , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This product expresses the Rat version of this receptor.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Glucagon

Sub Family:

Class B

Coupling:

Gs

Accession Number:

NP_036860.1

Target Species:

Rat

Cell Background:

CHO-K1

Usage

Product Type:

Stable Cell Lines

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

cAMP Detection

Clinical Relevance

Therapeutic Area:

Metabolic Diseases

Additional Information

Brand:

cAMP Hunter™