cAMP Hunter™ CHO-K1 RXFP4 Gi Cell Line

Background Information:

The cAMP Hunter™ RXFP4 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. relaxin-3) based activation of RXFP4 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type RXFP4 , a naturally Gs coupled GPCR. Upon activation of RXFP4 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Relaxin Family Peptide

Sub Family:

Class A

Coupling:

Gi/Go

Protein Name:

RXFP4

Protein Aliases:

G-protein coupled receptor 100|G-protein coupled receptor GPCR142|Insulin-like peptide INSL5 receptor|Relaxin family peptide receptor 4

Accession Number:

NM_181885.2

UniProt Number:

Q8TDU9

Gene Name:

RXFP4

Gene ID:

339403

Gene Aliases:

GPR100|RLN3R2

Target Species:

Human

Cell Background:

CHO-K1