cAMP Hunter™ CHO-K1 CRHR2 Gs Cell Line

Background Information:

The cAMP Hunter™ CRHR2 Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CRH, sauvagine) based activation of CRHR2 GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CRHR2 , a naturally Gs coupled GPCR. Upon activation of CRHR2 , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Corticotropin-Releasing Factor

Sub Family:

Class B

Coupling:

Gs

Protein Name:

CRF2

Protein Aliases:

CRF-R2|CRFR-2|Corticotropin-releasing hormone receptor 2|CRH-R-2|CRH-R2

Accession Number:

NM_001883.4

UniProt Number:

Q13324

Gene Name:

CRHR2

Gene ID:

1395

Gene Aliases:

CRF2|CRF-RB|HM-CRF|CRF2R|CRH2R

Target Species:

Human

Cell Background:

CHO-K1