Akt1/PKBalpha (deltaPH, S473D), active

Background Information:

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT activation relies on the PI3K pathway, and is recognized as a critical node in the pathway. The E17 hotspot is the most characterized of AKT1 mutations, and has been shown to result in activation of the protein. Mutations in AKT1 have also been shown to confer resistance to allosteric kinase inhibitors in vitro. GenBank M63167. S478G with regard to this accession, reported in EMBL BE206796. S473D conflict mimics phosphorylation of S473.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

Akt1 (PKBalpha)

Protein Aliases:

Protein kinase B|PKB|Protein kinase B alpha|PKB alpha|Proto-oncogene c-Akt|RAC-PK-alpha

Accession Number:

NM_001014431.1; NM_001014432.1; NM_005163.2

UniProt Number:

P31749

Gene Name:

AKT1

Gene ID:

207

Gene Aliases:

RAC|PKB|PRKBA|AKT

Target Species:

Human