AAK1, active

Background Information:

AAK1 (AP2 Associated Kinase 1) belongs to the SNF1 subfamily of serine/threonine protein kinases. This kinase is detected in brain, heart and liver, and plays an important role in regulating the clathrin-mediated endocytosis of the rabies virus, facilitating infection. Inhibitors of AAK1 are being studied as candidate therapeutics to disrupt the entry of viruses, including SARS-CoV-2, into target cells. It is also involved in positive regulation of Notch pathway signaling in mammals. [provided by RefSeq, Aug 2020]

Target Class:

Kinase

Family:

NAK

Sub Family:

Protein Ser/Thr

Protein Name:

AAK1

Protein Aliases:

Adaptor-associated kinase 1

Accession Number:

NM_080836.2

UniProt Number:

Q2M2I8

Gene Name:

AAK1

Gene ID:

22848

Gene Aliases:

KIAA1048|DKFZp686K16132

Target Species:

Human