STK39, active

Background Information:

STK39 (Serine/Threonine Kinase 39), also known as SPAK (Ste20-related Proline Alanine-rich Kinase), is a serine/threonine protein kinase that is involved in the regulation of ion transport and cell volume in response to changes in osmolarity. STK39 phosphorylates and activates several ion transporters and channels, including the sodium-potassium-chloride cotransporter (NKCC1) and the potassium chloride cotransporter (KCC2), and it has been suggested to play a role in the regulation of blood pressure and salt-sensitive hypertension. Research has also suggested that STK39 may play a role in the regulation of other cellular processes, including cell proliferation, cell cycle progression, and apoptosis. Additionally, STK39 has been implicated in several diseases, including hypertension, diabetes, and cancer, and efforts to develop small-molecule inhibitors of the kinase are underway as potential therapies for these conditions.

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

STLK3

Protein Aliases:

STE20/SPS1-related proline-alanine-rich protein kinase|DCHT|Serine/threonine-protein kinase 39

Accession Number:

NM_013233.1; NM_016289.2

UniProt Number:

Q9UEW8

Gene Name:

STK39

Gene ID:

27347

Gene Aliases:

DCHT|SPAK

Target Species:

Human