Biological Information

Background Information:

N-terminal 6His-tagged, recombinant, human Plk4, amino acids 1-303. Plk4 is a member of the serine/threonine protein kinase family. Plays a central role in centriole replication. Its role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation.

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Serine/threonine kinase

Protein Name:

PLK4

Protein Aliases:

Polo-like kinase 4|PLK-4|Serine/threonine-protein kinase 18|Serine/threonine-protein kinase Sak

Accession Number:

NM_014264.2

UniProt Number:

O00444

Gene Name:

PLK4

Gene ID:

10733

Gene Aliases:

Sak

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology