PathHunter® eXpress ErbB4/ErbB4 Dimerization Assay

Background Information:

The PathHunter® ErbB4/ErbB4 Dimerization eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This kit assesses ligand (e.g. neuregulin-1 Beta 2) induced dimerization of ErbB4/ErbB4 receptors. This product uses EFC technology. The cells included overexpress ErbB4 target protein fused to PK alongside ErbB4 target protein fused to EA. Upon ligand-induced dimerization of ErbB4/ErbB4, detectable EFC signal is produced. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.

Target Class:

Kinase

Family:

RTK

Sub Family:

Protein Tyrosine

Protein Name:

HER4

Protein Aliases:

human epidermal growth factor receptor 4

Accession Number:

NM_005235.2

UniProt Number:

Q15303

Gene Name:

ERBB4

Gene ID:

2066

Gene Aliases:

ALS19|HER4

Target Species:

Human

Cell Background:

U2OS