PathHunter® U2OS mMC5R β-Arrestin Cell Pool

Background Information:

The PathHunter® mMC5R Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. melanotan II) based activation of mMC5R GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mMC5R and EA-tagged β-Arrestin-2. Activation of mMC5R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

GPCR

Family:

Melanocortin

Sub Family:

Class A

Protein Name:

MC5

Protein Aliases:

MC-2

Accession Number:

NM_013596

UniProt Number:

P41149

Gene Name:

Mc5r

Gene ID:

17203

Target Species:

Mouse

Cell Background:

U2OS