Biological Information

Background Information:

The PathHunter® IL-11 Signaling Reporter Cell Line (HepG2) is a stable, engineered cell line that overexpresses IL11R. It can be used for studying drug candidates (small molecules or biologics) affecting the STAT3 pathway. This cell line enables assessment of STAT3 pathway stimulation based on changes in the expression of a STAT3 response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a STAT3 pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent. This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

Cytokine Receptor

Family:

IL-6 Receptor

Protein Name:

IL11RA

Protein Aliases:

IL-11R subunit alpha|IL-11R-alpha|IL-11RA

Accession Number:

NM_001142784.2; NM_139276.3

UniProt Number:

Q14626

Gene Name:

IL11RA

Gene ID:

3590

Target Species:

Human

Cell Background:

HepG2

Usage

Product Type:

Stable Cell Lines

Application:

Signaling Reporters

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Signaling

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy

Additional Information

Brand:

PathHunter®