Biological Information

Background Information:

The PathHunter® mADRA1B Cell Pool is a stable pool, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. phenylephrine) based activation of mADRA1B GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mADRA1B and EA-tagged β-Arrestin-2. Activation of mADRA1B stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

GPCR

Family:

Adrenoceptor

Sub Family:

Class A

Protein Name:

alpha1B

Protein Aliases:

Alpha-1B adrenoceptor

Accession Number:

NM_007416.3

UniProt Number:

P97717

Gene Name:

Adra1b

Gene ID:

11548

Target Species:

Mouse

Cell Background:

CHO-K1

Usage

Product Type:

Cell Pool

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

β-Arrestin Recruitment

Detection Method:

Chemiluminescence

Additional Information

Brand:

PathHunter®