Biological Information

Background Information:

The KILR® ARH-77 cell line is a stable, engineered target cell line to measure direct cell death mediated by immuno-oncology treatments (e.g. checkpoint inhibitors, checkpoint agonists, bispecifics, CAR-T, and more) via Antibody Dependent Cell-mediated Cytotoxicity (ADCC), Complement Dependent Cytotoxicity (CDC), and Antibody Dependent Cell Phagocytosis (ADCP). This product uses EFC technology. The cell line overexpresses a PL- tagged housekeeping gene. Once the cells have been lysed by effector cells, PL is released to the media, where EA contained in the detection kit produces an EFC signal proportional to the level of PL released. This allows for calculation of percent lysis of the KILR® cell line.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Species:

Human

Cell Background:

ARH-77

Usage

Product Type:

Stable Cell Lines

Application:

Cytotoxicity

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

Cytotoxicity

Detection Method:

Chemiluminescence

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology

Additional Information

Brand:

KILR®