Biological Information

Background Information:

IRAK4 is a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Target Class:

Kinase

Family:

TKL

Sub Family:

Protein Ser/Thr

Protein Name:

IRAK4

Protein Aliases:

Renal carcinoma antigen NY-REN-64

Accession Number:

NM_016123.1

UniProt Number:

Q9NWZ3

Gene Name:

IRAK4

Gene ID:

51135

Gene Aliases:

NY-REN-64

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Inflammation/Allergy