Biological Information

Background Information:

Nuclear factor kappa B (NF-kB) plays a critical role in the inducible expression of a large number of genes involved in immune, inflammatory and apoptotic processes. NF-kB is associated with IkB in cytoplasm, which inhibits NF-kB activity. IkB kinase (IKK), which consists of at least three proteins (IKK-1/a, IKK-2/b, and IKK-3/g), phosphorylates IkB and mediates IkB degradation. Once IkB is removed, NF-kB is free to enter the nucleus of the cell and transcriptionally activate its targeted genes. GenBank AF080158

Target Class:

Kinase

Family:

Other Protein Kinase

Sub Family:

Protein Ser/Thr

Protein Name:

IKKbeta

Protein Aliases:

IKK-B|IKK-beta|IkBKB|I-kappa-B kinase 2|IKK2|Nuclear factor NF-kappa-B inhibitor kinase beta|NFKBIKB

Accession Number:

NM_001556.1

UniProt Number:

O14920

Gene Name:

IKBKB

Gene ID:

3551

Gene Aliases:

IKK2|NFKBIKB|IKK-beta|IKKB

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

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Assay Information

Assay Type:

Enzymatic

Clinical Relevance

Therapeutic Area:

Oncology/Immuno-Oncology