GRK4, active

Background Information:

GRK4 (G protein-coupled receptor kinase 4) is a serine/threonine protein kinase that belongs to the GRK family of kinases. It is primarily expressed in the kidney, where it plays a role in the regulation of blood pressure and sodium homeostasis. GRK4 has been implicated in the development of hypertension and renal disease, as its upregulation or over activation can lead to an increase in blood pressure and sodium reabsorption. Research has also suggested that GRK4 may play a role in the pathogenesis of several other diseases, including heart failure and obesity. In heart failure, GRK4 has been shown to be upregulated, and may contribute to the development of cardiac dysfunction. In obesity, GRK4 has been implicated in the regulation of adipocyte differentiation and metabolism, and may play a role in the development of insulin resistance.

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

GRK4

Protein Aliases:

G protein-coupled receptor kinase GRK4|ITI1

Accession Number:

BC117320.1

UniProt Number:

P32298

Gene Name:

GRK4

Gene ID:

2868

Gene Aliases:

GPRK4

Target Species:

Human