ChemiSCREEN™ Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ Rhesus Macaque CCR5 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MIP, RANTES) based activation of CCR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR5 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the rhesus macaque version of the protein.

Target Class:

GPCR

Family:

Chemokine

Sub Family:

Class A

Protein Name:

CCR5

Protein Aliases:

CC-CKR-5|CCR-5|CCR5|CHEMR13|HIV-1 fusion coreceptor|CD antigen CD195

Accession Number:

NM_001042773.2

UniProt Number:

P51682

Gene Name:

CCR5

Gene ID:

735311

Gene Aliases:

CKR-5|CC-CKR-5|CKR5|CD195|IDDM22

Target Species:

Rhesus Macaque

Cell Background:

Chem-1