ChemiSCREEN™ MCH2 Melanin-concentrating Hormone Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ MCH2 Melanin-concentrating Hormone Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. MCH) based activation of MCHR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses MCHR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of MCHR2 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Melanin-Concentrating Hormone

Sub Family:

Class A

Protein Name:

MCH2

Protein Aliases:

MCH-R2|MCHR-2|G-protein coupled receptor 145|GPRv17|MCH-2R|MCH2|MCH2R

Accession Number:

AY562946

UniProt Number:

Q969V1

Gene Name:

MCHR2

Gene ID:

84539

Gene Aliases:

SLT|MCH2|MCH2R

Target Species:

Human

Cell Background:

Chem-1