ChemiSCREEN™ CB1 Cannabinoid Receptor Stable Cell Line

Background Information:

The ChemiSCREEN™ CB1 Cannabinoid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. cannabinoids, CP 55,940) based activation of CNR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CNR1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CNR1 , the resulting calcium activity can be fluorescently assayed.
This stable engineered cell line is provided as two vials of cryopreserved cells.

Target Class:

GPCR

Family:

Cannabinoid

Sub Family:

Class A

Protein Name:

CB1

Protein Aliases:

CB1|CANN6

Accession Number:

AY225225

UniProt Number:

P21554

Gene Name:

CNR1

Gene ID:

1268

Gene Aliases:

CB1K5|CB-R|CB1|CANN6|CB1A

Target Species:

Human

Cell Background:

Chem-1