TrkB, active

N-terminal 6His-tagged recombinant, human TrkB amino acids 455-end.

Catalog #: 14-507


Biological Information
Background Information:
Three tyrosine kinase receptors, designated TRKA, TRKB and TRKC, have been identified that selectively bind NGF, BDNF and NT-3, respectively; NT-4/5 also binds to the TRKB (TrkB tyrosine kinase, Trk-B, GP145-TrkB, BDNF/NT growth factors12) receptor. NGF binds to their specific TRK receptor to stimulate intracellular signaling pathways leading to specific protein phosphorylations and differential gene inductions. TRK receptor kinases engage the activation of a branched proto-oncoprotein signaling pathway involving Shc, Src, Ras, Raf, mitogen-activated protein kinase, and other downstream effectors. Inhibitors of TRKB may be useful in the treatment of cancer as well as anorexia and bulimia nervosa. GenBank U12140
Target Class:
Accession Number:
Refer to CoA for Accession Number
Target Name:
Target Aliases:
NTRK2, GP145-TrkB, TRKB, Trk-B
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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14-507x Datasheet

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