TLK1 protein is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. GenBank NM_012290
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