| Biological Information | |
|---|---|
| Background Information: | PRMT1 (Protein arginine methyltransferase 1) is a protein arginine methyltransferase that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to the guanidino nitrogen of arginine residues in proteins. PRMT1 specifically targets the omega nitrogen of arginine residues, and catalyzes the formation of asymmetric dimethylarginine (ADMA) residues, which can modulate the structure and function of target proteins.
PRMT1 has been shown to play a role in the regulation of gene expression by modulating the function of transcription factors, co-regulators, and RNA polymerase II.
PRMT1 has been identified as a potential therapeutic target for various diseases, including cancer and cardiovascular diseases. Its inhibition has been shown to suppress tumor growth and improve heart function in animal models of heart disease. |
| Target Class: | Epigenetic Protein |
| Family: | Histone methyltransferase |
| Accession Number: | NP_001527.3 |
| Target Name: | PRMT1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
PRMT1
N-terminal 6His-tagged recombinant, human PRMT1 amino acids 30-371.
Datasheets
EPI053 Datasheet
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