| Biological Information | |
|---|---|
| Background Information: | The PrecisION® hCav1.2 α1C/β2a/α2δ1 Recombinant Stable Cell Line is a stable, engineered cell line for use in studying Cav1.2 ion channels, including drug candidates which affect channel function. This cell line enables assessment of ion channel function via detection of electrophysiological signals. The included cell line overexpresses Cav1.2 ion channels. Upon ligand/agonist induced channel activation, response can be detected via automated or manual electrophysiological techniques. This stable modified cell line is provided as two vials of cryopreserved cells. |
| Target Class: | Ion Channel |
| Accession Number: | AJ224873, AF423189, NM_000722 |
| Target Name: | CACNA1C, CACNB2, CACNA2D1 |
| Target Aliases: | calcium channelvoltage-dependentcalcium voltage-gated channel alpha subunit Cav1.2α1C cardiac or smooth muscle dihydropyridine receptorcardiac or smooth muscle L-type Ca2+ channelCACH2CACN2CACNL1A1LQT8 L typealpha-1 polypeptideL-type calcium channel alpha-1 subunitL typealpha 1C subunitcalcium voltage-gated channel auxiliary subunit beta 2α1C cardiac or smooth muscle dihydropyridine receptorcardiac or smooth muscle L-type Ca2+ channelCACH2CACN2CACNL1A1LQT8 L-type calcium channel alpha-1 subunitL typealpha 1C subunitcalcium voltage-gated channel auxiliary subunit alpha2 delta 1CACNL2ACACNA2MHS3LINC01112long intergenic non-protein coding RNA 1112alpha 2/delta subunit 1 |
| Target Species: | Human |
| Cell Background: | HEK293 |
| Usage | |
| Product Type: | Stable Cell Lines |
| Application: | Electrophysiology |
| Storage Conditions: | Short term (24 h): Store in vapor phase of liquid nitrogen. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Functional |
| Assay Measures: | Electrophysiology |
| Additional Information | |
| Brand: | PrecisION® |
PrecisION® hCav1.2 alpha1C/beta2a/alpha2/delta1 Recombinant Stable Cell Line
The PrecisION® hCav1.2 α1C/β2a/α2/δ1 Recombinant Stable Cell Line measures Cav1.2 ion channel activity via electrophysiological measurements. This cell line ships as two vials of cryopreserved cells.
User Manuals & Protocols
70-430 PrecisION Ion Channel Cell Lines_Rev_2.0
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CYL3051 Datasheet
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