PI3 Kinase (p110alpha/p65alpha)

Complex of N-terminal 6His-tagged recombinant, human full length p110α and untagged, recombinant, full length Human p65α.

Catalog #: 14-790


Biological Information
Background Information:
PI3 Kinase plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. It also participates in cellular signaling in response to various growth factors and involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. PI3K regulates invadopodia formation through the PDPK1-AKT1 pathway, and participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. In addition to its lipid kinase activity, it displays a serine-protein kinase activity that results in the autophosphorylation of the p85alpha regulatory subunit as well as phosphorylation of other proteins such as 4EBP1, H-Ras, the IL-3 beta c receptor and possibly others.
Target Class:
Lipid Kinase
Accession Number:
Target Name:
Target Aliases:
PIK3CA, PI3K, MGC142161, p110-alpha, MGC142163
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
6 months at -70°C
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14-790x Datasheet

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