PathHunter® U2OS FGFR3(G380R)/FGFR3(G380R) Dimerization Cell Line

The PathHunter® U2OS FGFR3(G380R)/FGFR3(G380R) Dimerization Cell Line measures ligand-induced dimerization of FGFR3(G380R)/
FGFR3(G380R) . This cell line ships as two vials of cryopreserved cells. G380R version.

Catalog #: 93-1091C3 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® FGFR3(G380R)/ FGFR3(G380R) Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. FGF-18) induced dimerization of FGFR3/FGFR3 receptors. This product uses EFC technology. The cell line included overexpresses FGFR3G380R target protein fused to PK alongside FGFR3G380R target protein fused to EA. Upon ligand-induced dimerization of FGFR3(G380R)/ FGFR3(G380R) , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the G380R version of FGFR3.
Target Class:	Kinase
Family:	Receptor Typosine Kinase (RTK): Growth Factor Receptor
Sub Family:	Protein Tyrosine
Accession Number:	NM_000142.4
Target Name:	FGFR3(G380R)/FGFR3(G380R)
Target Aliases:	Fibroblast growth factor receptor 3, G380R mutant
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®