PathHunter® U2OS ACVRL1/ACVR2 Dimerization Cell Line

The PathHunter® U2OS ACVRL1/ACVR2 Dimerization Cell Line measures ligand-induced dimerization of ACVRL1/ACVR2 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0963C3 Size: 2 vials
Inquire
Biological Information
Background Information:
The PathHunter® ACVRL1/ACVR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. GDF2/BMP9) induced dimerization of ACVRL1/ACVR2 receptors. This product uses EFC technology. The cell line included overexpresses ACVR2 target protein fused to PK alongside ACVRL1 target protein fused to EA. Upon ligand-induced dimerization of ACVRL1/ACVR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Kinase
Family:
Ser/Thr Kinase: Type I Receptor
Sub Family:
Protein Ser/Thr
Accession Number:
NM_000020.0
Target Name:
ACVRL1/ACVR2
Target Aliases:
activin receptor, Activin A receptor type II-like 1, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I, ACVR2A, ACTRII, ACVR2
Target Species:
Human
Cell Background:
U2OS
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Dimerization
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-303 PathHunter Dimerization Assay REV3 User Manual

View Document

Datasheets

93-0963C3

View Document
AssayComplete™ Thawing Reagent T3
92-4103TR
100 mL

$249.00

AssayComplete™ Freezing Reagent F3
92-5103FR
2 x 50 mL

$339.00

AssayComplete™ Cell Detachment Reagent
92-0009
50 mL

$109.00

AssayComplete™ Cell Plating 22 Reagent
93-0563R22A
100 mL

$339.00

PathHunter® Flash Detection Kit
93-0247
Inquire
AssayComplete™ Cell Culture Kit-103
92-3103G
Kit

$397.00