PathHunter® Jurkat PD1 Pathway Reporter Cell Line

The PathHunter® Jurkat PD1 Signaling Pathway Reporter Cell Line overexpresses PD1 and measures NFAT pathway activation through detection of induced expression levels of a tagged reporter protein. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1153C19 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® Jurkat PD1 Signaling Pathway Reporter Cell Line is a stable, engineered cell line that overexpresses PD1. It can be used for studying drug candidates (small molecules or biologics) affecting the NFAT pathway. This cell line enables assessment of NFAT pathway stimulation based on changes in the expression of a NFAT response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a NFAT pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells
Target Class:	Checkpoint Receptor
Family:	IgSF (immune inhibitory Receptor)
Accession Number:	NM_005018.2
Target Name:	PD-1
Target Aliases:	PDCD1, Programmed cell death protein 1, PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1
Target Species:	Human
Cell Background:	Jurkat

Usage
Product Type:	Stable Cell Lines
Application:	Signaling Reporters
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Signaling
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®