The PathHunter® Jurkat PD1 Signaling Pathway Reporter Cell Line is a stable, engineered cell line that overexpresses PD1. It can be used for studying drug candidates (small molecules or biologics) affecting the NFAT pathway. This cell line enables assessment of NFAT pathway stimulation based on changes in the expression of a NFAT response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a NFAT pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells
IgSF (immune inhibitory Receptor)
PDCD1Programmed cell death protein 1PD1PD-1CD279SLEB2hPD-1hPD-lhSLE1
Stable Cell Lines
Short term (24 h): Store in vapor phase of liquid nitrogen.
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PathHunter® Jurkat PD1 Pathway Reporter Cell Line
User Manuals & Protocols