PathHunter® HEK 293 IL22RA/IL10RB1 Dimerization Cell Line

The PathHunter® HEK 293 IL22RA/IL10RB1 Dimerization Cell Line measures ligand-induced dimerization of IL22RA/IL10RB1 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1026C1 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® IL22RA/IL10RB1 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IL-22) induced dimerization of IL22RA/IL10RB1 receptors. This product uses EFC technology. The cell line included overexpresses IL22RA target protein fused to PK alongside IL10RB1 target protein fused to EA. Upon ligand-induced dimerization of IL22RA/IL10RB1 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	Interleukin Receptor
Accession Number:	NM_021258.3
Target Name:	IL22RA/IL10RB1
Target Aliases:	Interleukin 22 receptor, Interleukin 22 receptor alpha 1, interleukin 10 receptor, IL22R, CRF2-9, IL22R1, CDW210B, CRF2-4, CRFB4, D21S58, D21S66, IBD25, IL-10R2, IL-10RB
Target Species:	Human
Cell Background:	HEK293

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Inflammation/Allergy

Additional Information
Brand:	PathHunter®