PathHunter® CD200R Signaling Cell Line (Jurkat)

The PathHunter® Jurkat CD200R Signaling Cell Line measures CD200R signal by recruitment of SH2 domain protein to the activated receptor. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1176C19 Size: 2 vials

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Biological Information
Background Information:	The PathHunter CD200R Checkpoint Signaling cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting signaling checkpoints. This cell line enables assessment of ligand (e.g. CD200) based activation of CD200R receptors via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged CD200R target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells
Target Class:	Checkpoint Receptor
Family:	IgSF (immune inhibitory Receptor)
Sub Family:	CD Molecules
Accession Number:	NC_000003.12
Target Name:	CD200
Target Aliases:	MOX1, MOX2, MRC, OX-2
Target Species:	Human
Cell Background:	Jurkat

Usage
Product Type:	Stable Cell Lines
Application:	Signaling Reporters
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Signaling

Clinical Relevance
Therapeutic Area:	Oncology/Immuno-Oncology

Additional Information
Brand:	PathHunter®