| Biological Information | |
|---|---|
| Background Information: | PAR-1Bα Protein has a role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. The human EMK1 was shown to be encoded by a single mRNA ubiquitously expressed.
GenBank AF387638 |
| Target Class: | Kinase |
| Accession Number: | NM_001039468.1; NM_001039469.1; NM_004954.3; NM_017490.2 |
| Target Name: | PAR-1Ba |
| Target Aliases: | MARK2, MGC99619, EMK1, PAR-1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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PAR-1Balpha, active
N-terminal 6His-tagged recombinant, human full length PAR-1Bα.
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14-544x Datasheet
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