| Biological Information | |
|---|---|
| Background Information: | MuSK (Muscle Associated Receptor Tyrosine Kinase) is a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. [provided by RefSeq, Oct 2009] |
| Target Class: | Kinase |
| Accession Number: | NM_005592.1 |
| Target Name: | MuSK |
| Target Aliases: | MUSKMuSKMGC126323MGC126324 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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MuSK, active
N-terminal 6His-tagged recombinant, human MuSK amino acids 530-end.
Datasheets
14-634x Datasheet
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