| Biological Information | |
|---|---|
| Background Information: | MLK4 (Mixed-Lineage Kinase 4) is a serine/threonine protein kinase that belongs to the mixed lineage kinase family of MAP3Ks (mitogen-activated protein Kinase kinase kinases). MLK4 has been shown to activate several downstream signaling pathways, including the c-Jun N-terminal kinase (JNK) pathway, the p38 MAPK pathway, and the NF-κB pathway, and it has been suggested to play a role in the regulation of cell survival, apoptosis, and inflammation.
Research has suggested that MLK4 may also be involved in the regulation of several other physiological processes, including cardiovascular function and cancer progression. MLK4 has been implicated in the development and progression of several types of cancer, including breast cancer, prostate cancer, and pancreatic cancer, and efforts to develop small-molecule inhibitors of the kinase are underway as potential therapies for these conditions. |
| Target Class: | Kinase |
| Accession Number: | BC136649.1 |
| Target Name: | MLK4 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
MLK4, active
N-terminal GST-tagged recombinant, human MKL4 amino acids 114-420.
Datasheets
16-051x Datasheet
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