| Biological Information | |
|---|---|
| Background Information: | JMJD2D (Jumonji domain-containing protein 2D), also known as KDM4D, is a histone demethylase that belongs to the JmjC domain-containing protein family. It specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression. JMJD2D is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis.
JMJD2D has been shown to play a role in the development of several types of cancer, including breast, ovarian, and prostate cancers. It has also been implicated in the regulation of cellular metabolism, including the response to hypoxia and glucose metabolism. Therefore, JMJD2D has emerged as a potential target for the development of novel therapeutics for cancer and metabolic diseases. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | JMJD2D |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
JMJD2D
N-terminal 6His-tagged recombinant amino acids 1-358, human JMJD2D.
Datasheets
EPI032 Datasheet
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