InCELL Hunter™ Jurkat RIPK1 Kinase Binding Cell Line

The InCELL Hunter™ Jurkat RIPK1 Kinase Binding Cell Line measures target engagement via compound-induced stabilization of RIPK1 target protein. This cell line ships as two vials of cryopreserved cells.

Catalog #: 96-0076C19 Size: 2 vials

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Biological Information
Background Information:	The InCELL Hunter™ Jurkat RIPK1 Kinase Binding Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with kinases. This cell line enables assessment of compound-engagement-based stabilization of RIPK1 via detection of RIPK1 levels. This product uses EFC technology. The cell line included overexpresses RIPK1 target protein fused to PL. In the absence of compound that binds and stabilizes the target, this protein is denatured by the heat treatment and no EFC signal is produced. When compound engages and heat-stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Kinase
Family:	TK-Like Kinase
Sub Family:	Protein Ser/Thr
Target Name:	RIPK1
Cell Background:	Jurkat

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Target Engagement
Detection Method:	Chemiluminescence

Additional Information
Brand:	InCELL Hunter™