| Biological Information | |
|---|---|
| Background Information: | Glycogen synthase kinase 3 (GSK3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. There exists two isoforms of GSK3, GSK3A and GSK3B, and they are strictly regulated via phosphorylation. GSK3 has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK3A also has been inhibited by activation of the canonical Wnt pathway, resulting in increased catenin that drives human mesenchymal stem cells to osteoblasts.
GenBank NM_019884. The recombinant GSK3a sequence deviates from that published in NM_019884 by a single amino acid substitution, S449A. This substitution has been reported elsewhere, GenBank 2641993. |
| Target Class: | Kinase |
| Accession Number: | NM_019884.2 |
| Target Name: | GSK3α |
| Target Aliases: | GSK3ADKFZp686D0638 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
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GSK3alpha, active
N-terminal 6His-tagged recombinant, human GSK3α amino acids 2-end.
Datasheets
14-492x Datasheet
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