GSK3alpha, active

N-terminal 6His-tagged recombinant, human GSK3α amino acids 2-end.

Catalog #: 14-492


Biological Information
Background Information:
Glycogen synthase kinase 3 (GSK3) is a protein kinase that was originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism. There exists two isoforms of GSK3, GSK3A and GSK3B, and they are strictly regulated via phosphorylation. GSK3 has been shown to phosphorylate a number of different cellular proteins, including p53, c-Myc, c-Jun, heat shock factor-1 (HSF-1), and cyclin D1. GSK3A also has been inhibited by activation of the canonical Wnt pathway, resulting in increased catenin that drives human mesenchymal stem cells to osteoblasts. GenBank NM_019884. The recombinant GSK3a sequence deviates from that published in NM_019884 by a single amino acid substitution, S449A. This substitution has been reported elsewhere, GenBank 2641993.
Target Class:
Accession Number:
Target Name:
Target Aliases:
GSK3A, DKFZp686D0638
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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14-492x Datasheet

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