| Biological Information | |
|---|---|
| Background Information: | The receptor tyrosine kinase FLT-3 (fms-related tyrosine kinase 3, STK1) appears to play an important role in the development of hematopoietic stem cells, dendritic cells, B progenitor cells, and natural killer (NK) cells. On binding FLT3 ligand, the wild-type receptor dimerizes, activating its tyrosine kinase domain with resultant autophosphorylation. RAS-GAP, PLC-g, PI3-kinase, STAT5, and ERK1/2 are important signaling proteins linked to activation of FLT3. FLT3 is aberrantly expressed in the malignant cells in the majority of patients with acute myeloid leukemia (AML).
GenBank NM_004119 |
| Target Class: | Kinase |
| Family: | Receptor Tyrosine Kinase |
| Accession Number: | NM_004119.2 |
| Target Name: | FLT3 |
| Target Aliases: | FLT3, STK-1, FLK2, CD135, OTTHUMP00000042340, STK1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 6 months at -70°C |
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Flt-3 (D835Y), active
N-terminal GST-tagged recombinant, human Flt3 amino acids 564-end, containing the mutation D835Y.
Datasheets
14-610x Datasheet
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