CHO-K1 EDG3 Gq Cell Line

The CHO-K1 EDG3 Gq Cell Line measures EDG3 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-1007C2 Size: 2 vials

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Biological Information
Background Information:	The EDG3 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. S1P) based activation of EDG3 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses EDG3 , a naturally Gq coupled GPCR. Upon activation of EDG3 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Lysophospholipid (S1P) Receptors
Sub Family:	Class A
Coupling:	Gq
Accession Number:	NM_005226
Target Name:	EDG3
Target Aliases:	Sphingosine 1-phosphate receptor 3, C9orf108, C9orf47, EDG-3, SIPR3, LPB3, S1P3, bA791O21.3
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Calcium Flux
Detection Method:	Chemiluminescence

Additional Information
Brand:	DiscoverX