Biological Information | |
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Background Information: | Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK2 might have a redundant and supportive role in checkpoints, but its role in ionizing radiation-induced apoptosis is more prominent. However, its role in other DNA-damage-induced apoptosis mechanisms is less well established. CHK2 inhibitors are expected to sensitize proliferating cells to chemotherapy-induced apoptosis.
GenBank NM_007194 |
Target Class: | Kinase |
Accession Number: | NM_001005735.1; NM_007194.3; NM_145862.2 |
Target Name: | CHK2 |
Target Aliases: | CHEK2, HuCds1, CHK2, LFS2, RAD53, bA444G7, CDS1, OTTHUMP00000028871, PP1425, Cds1 |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
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