| Biological Information | |
|---|---|
| Background Information: | Checkpoint kinase (CHK) is activated by a broad spectrum of DNA-damaging agents, including DNA-strand-breaking agents such as ionizing radiation and topoisomerase inhibitors, and those agents that cause replication stress such as ultraviolet light, hydroxyurea and 5-fluorouracil. CHK1 regulates numerous checkpoint pathways, including S-phase and G2-M checkpoints. Other potential CHK1 functions include replication, chromatin remodeling and DNA repair. CHK1 inhibitors may sensitize tumors to chemotherapy and radiotherapy.
GenBank AF016582 |
| Target Class: | Kinase |
| Accession Number: | NM_001274.3 |
| Target Name: | CHK1 |
| Target Aliases: | CHEK1, CHK1 |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
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CHK1, active
N-terminal GST-tagged recombinant, human full length CHK1.
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14-346x Datasheet
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