The cyclin-dependent kinases (CDKs), a subfamily of protein kinases, promote cell cycle progression. In mammals, nine different CDKs (cdk 1 to cdk 9; cdk 1 is better known as cdc 2) have been identified. CDKs are regulated on various levels including binding of proteins (cyclins, inhibitors, and assembly factors), protein degradation, transcriptional control, localization, and multiple phosphorylations. This leads to timely regulation of CDK activity, allowing progression from one cell cycle phase to the next. The cdk1 induces entry into M-phase of the cell cycle in eukaryotes. GenBank NM_001786 / EMBL M25753
Serine/Threonine Kinase: CDK1 subfamily
Drug Discovery & Development
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Cdk1/cyclin B, active