| Biological Information | |
|---|---|
| Background Information: | CaM Kinase I γ (Calcium/Calmodulin-Dependent Protein Kinase I gamma) is a serine/threonine protein kinase that belongs to the CaM Kinase family of kinases. It is primarily expressed in the brain, where it plays a critical role in neuronal signaling and plasticity.
CaM Kinase I γ is activated by binding of calcium and calmodulin, which leads to autophosphorylation and activation of the kinase. It has been shown to phosphorylate a variety of substrates, including ion channels, transcription factors, and other kinases, which contributes to the regulation of neuronal excitability, gene expression, and synaptic plasticity. Research has suggested that CaM Kinase I γ plays a critical role in several neurological and psychiatric disorders, including Alzheimer's disease, schizophrenia, and bipolar disorder. |
| Target Class: | Kinase |
| Family: | CAMK1 family |
| Accession Number: | NM_020439.2 |
| Target Name: | CaM Kinase I γ |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
CaM Kinase I gamma, active
N-terminal GST-tagged recombinant, human full length CaM Kinase Iγ.
Datasheets
14-967x Datasheet
View Document