Akt2/PKBbeta (deltaPH, S474D), active

N-terminal 6His-tagged recombinant, human PKBβ, amino acids 120-481, S474D; activated by PDK1.

Catalog #: 14-339


Biological Information
Background Information:
Akt2, also known as Protein Kinase B Beta, is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains, which is involved in signaling pathways. Akt2 serves as an oncogene in the tumorigenesis of cancer cells For example, its overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phosphorylating several known proteins, and has also been implicated in insulin signaling. EMBL M95936. The recombinant protein contains an amino acid substitution, S474D, with reference to the native sequence. This mimics the phosphorylation of S474.
Target Class:
Ser/Thr Kinases: Akt Family
Accession Number:
Target Name:
Target Aliases:
AKT serine/threonine kinase 2, PKBB, PRKBB, HIHGHH, PKBBETA, RAC-BETA
Target Species:
Product Type:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
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14-339x Datasheet

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