Biological Information

Background Information:

The PathHunter® mPTGIR Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. prostaglandin I2, beraprost) based activation of mPTGIR GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mPTGIR and EA-tagged β-Arrestin-2. Activation of mPTGIR stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.

Target Class:

GPCR

Family:

Prostanoid

Sub Family:

Class A

Protein Name:

IP

Protein Aliases:

PGI receptor|PGI2 receptor|Prostanoid IP receptor|Prostacyclin receptor

Accession Number:

NM_008967.3

UniProt Number:

E9PY53

Gene Name:

Ptgir

Gene ID:

19222

Gene Aliases:

IP|PRIPR

Target Species:

Mouse

Cell Background:

CHO-K1

Usage

Product Type:

Cell Pool

Application:

Drug Discovery & Development

Storage Conditions:

Store in vapor phase of liquid nitrogen.

Usage disclaimer:

These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information

Assay Type:

Cell Based

Assay Measures:

β-Arrestin Recruitment

Detection Method:

Chemiluminescence

Additional Information

Brand:

PathHunter®