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New Target Specific Data Sites for ß-Arrestin and Kinase Products!
New Products
Over 100 PathHunter GPCR ß-Arrestin Products Available!
New Products
DiscoveRx now offers 99 qualified PathHunter GPCR ß-Arrestin Cell Pools expressing Gi, GS and Gq coupled receptors
Now you can directly and easily measure Gi, Gs, or Gq GPCR activation in single-addition assays. PathHunter ß-Arrestin Assays are revolutionary high-throughput screening assays for monitoring GPCR activation following ligand stimulation without an imaging instrument or fluorescent protein tag. Instead, the assays detect GPCR activation through ß-Arrestin binding to the expressed GPCR of interest, measuring the interaction of the two proteins using enzyme fragment complementation in a fast and easy microtitre plate format. Contact a DiscoveRx Sales Representative for more information on the qualified GPCRs.
PathHunter™ Receives Frost & Sullivan's 2006 Technology Innovation Award
Technology Award
Frost & Sullivan Recognizes DiscoveRx’s Innovative Assay Technology for Drug Screening and Overall Achievements in Intact Cell-Based Assays.
Palo Alto, Calif.- Sept. 06, 2006 — Frost & Sullivan selected DiscoveRx Corp. as the recipient of the 2006 Frost & Sullivan Award for Technology Innovation for its development of the PathHunter™, an innovative protein trafficking platform technology. In its simplest format, this assay system allows users to monitor signaling pathways using translocation in whole cells. Today, DiscoveRx offers a broad range of assays and services for evaluating compound effects on various cellular pathways including their most recent addition, PathHunter Beta-Arrestin assays for GPCR activation.
Coelenterazine h for GPCR aequorin assays
New Product
Calcium No Wash kit for GPCR assays
New Product
PathHunter™ Mitotic Index Assays
Homogeneous, Cell-Based assays for HTS
PathHunter Mitotic Index assays are ready to use cellular assays that utilize DiscoveRx EFC biosensor technology to advance cancer therapeutic screening in a whole cell context, without the use of expensive imaging workstations. PathHunter assays provide a simple and convenient homogeneous assay with chemiluminescence signal generation, designed with optimal precision and performance for high quality automated screening.
Like other PathHunter technologies, the Mitotic Index assays are engineered biosensor cell lines with separate nuclear and cytoplasmic fragments of Beta-galactosidase. Complementation of the separate fragments occurs during the disassembly of the nuclear membrane at mitosis, enabling simple yet informative assays for screening or pathway profiling.
ADP Hunter™ - Universal Kinase Assay for HTS
New Product
With low compound interference, high ATP tolerance and high precision, ADP Hunter is ideally suited for HTS. ADP Hunter is a generic ADP accumulation assay and is applicable to any kinase, thus minimizing assay development time.
SBS 2005, Geneva - DiscoveRx presents 5 technical posters
Technical Poster Presentation
SBS 2005, Geneva - DiscoveRx presented 5 technical posters featuring:
1. PathHunter CHO-K1 GR assay for Monitoring Nuclear Translocation
2. PathHunter Mitotic Index Assay
3. ADP, generic phosphorylation technologies for determination of Km, Ki and Enzyme Kinetics
4. ADP Hunter, generic phosphorylation assay for screening
5. ProLabel AR Degradation Assay
PathHunter™ Whole-cell Assay for Protein Translocation
New Product
A Novel Cell-Based Assay Format WithApplications In Both Primary Screening And Pathway Profiling.
PathHunter bridges the gap between High Throughput Screening (HTS) and High Content Analysis (HCA), by applying EFC complementation in a whole cell in vivo detection system. The PathHunter product family is a whole-cell system that utilizes positional complementation within the context of the living cell to report target translocation.
ADP Quest™ - Universal Kinase Activity Assay
New Product
Perform Detailed Kinetic or Endpoint Assays with a Single, Generic Kit That Monitors ADP Produced by Any Phosphotransferase Activity
Measuring Phosphodiesterase Activity with HitHunter™ cAMP II
New Product Application
PDEs have become novel therapeutic drug targets. They share common catalytic sequences but they differ in substrate specificity, tissue distribution and expression, sensitivity to inhibitors and mode of regulation. HitHunter™ cAMP II (90-0034) has been adapted for assessing the effect of PDE inhibitors or catalytic PDE activity on cAMP in a homogeneous, non-radioactive assay format.
PhosphoQuest™ ELISAs for cell based kinases
New Products
PhosphoQuest Enzyme Immunometric Assay (EIA) kits are complete kits for the quantitative determintation of phospho-kinases in cell lysates.
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