DiscoveRx Assay Newsletter

Welcome to another edition of DiscoveRx Assay Newsletter packed with information on new product launches, novel applications, therapeutic focus & promotions.

DiscoveRx strives to provide innovative cutting edge products for GPCR, Kinases, NHR and protease screening and profiling. We now offer over 450 functional cell based assays for all major drug target classes. For a complete list of products visit www.discoverx.com

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What's New?

Novel Applications

Therapeutic Focus

Promotions & Events

Introducing 32 PathHunter™ GPCR Internalization/Endocytosis Assays

•Direct measure of internalized receptors localized to the early
 endosome
•Two novel assay format available
•Quantitative, single-addition protocol with large assay windows
•Ideal for detection of HIV viral entry inhibitors

PathHunter GPCR Endocytosis assays allow you to differentiate between endocytosing and non-endocytosing ligands ... Read more»

PathHunter™ β-Arrestin Ortholog GPCR Assays for Effective Compound Dosing Prior to Animal Studies

•80 Mouse, Simian, Rat, and Canine GPCR Assays available
•Pre-validated using both human and Mouse ligands
•Tolerant to up to 80% serum enabling analyte screening direct
 from human or mouse serum samples
•Determine effective dosing and specificity of lead compounds prior
 to expensive animal models

PathHunter™ β-Arrestin Ortholog GPCR Assays allow rapid and efficient
species selectivity or SAR/Lead Optimization in under 3 hours... Read more»

LumiLITE™ Microplate Reader

•Dedicated luminometer, competitively priced (< 10k)
•Extremely sensitive (comparable to ViewLux)
•Easy to use
•Built-in curve fitting features
•Compatible with all of DiscoveRx's (HitHunter™ & PathHunter™) assays
• More»...

New Releases

NEW cAMP Hunter™ Gi/Gs Cell Lines
•View cAMP response of Serotonin receptors (New!)
•Over 80 Gi/Gs Cell Lines now available!

PathHunter™ β-Arrestin
•Lysophospholipid Family is Now Complete! Choose LPA1, LPA2,
 LPA3, S1P1, S1P2, S1P3, S1P4 or S1P5
•Class A Orphans GPR55 and GPR81 validated with putative ligands
•Dopamine Receptors DRD2L, DRD2S, and DRD3
•Neuropeptide W/Neuropeptide B Receptors NPBWR1 and NPBWR2
•> 70 Mouse and Rat Ortholog GPCR Cell lines also available

New PathHunter™ Cell-based Kinase Assays
•Receptor Tyrosine Kinase Assays: View agonist and inhibitor response
 to Neurotrophin receptor TrkC-P75
•Over 15 receptor tyrosine kinases are available!
 Other kinase assays available 1κB, FOXO3-Akt, CSF3R...

Click here for a complete list of new product launches