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PathHunter™ Cell-Based Protease Assay

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Proteases

– Unique functional cell-based screening solutions

PathHunter™ Cell-Based Protease Assays


Frost & Sullivan selected DiscoveRx Corporation as the recipient of the 2006 Frost & Sullivan Award for Technology Innovation for its development of the PathHunter™, an innovative protein trafficking platform. PathHunter cell-based protease assays provides a novel, homogeneous approach for detection of secreted protein utilizing the prorietary Enzyme fragment complementation (EFC) technolgoy. In the identification of inhibitors to proteases, pharmarceutical companies consider specificity as a key assay feature. First generation MMP inhibitors failed in late stages of drug development because of promiscuity of proteases that resulted in a lot of side effects. PathHunter cell based protease assays thus provide specificity and cellular context offering a simple solution to the complex world of proteases.

Product Features

Cell-based functional assay
Ideal for high throughput screening
Chemiluminescent assay reduces false positives
Simple, two addition protocol

For instrument compatibility, please click here.

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Available Collaterals

Click here to view what we have available!

PathHunter™
Protease Assays
Applications
Catalog #
Product
Inserts
Price
PathHunter™
PCSK9
Cell-Based
Protease Assay
A PathHunter cell line
for studying dosage, potency, effect of small molecule inhibitors of PCSK9 secretion
93-0440C1
PathHunter™
ADAM10 Cell-Based
Protease Assay
A PathHunter cell
line for ADAM10 screening
93-0445C1
PathHunter™
Secretion
Detection Kit
Detecting and
measuring ProLabel (PL) or ProLink (PK) tagged proteins in whole cells following secretion into cell culture media.
93-0273
EAstern Blot
Assay Kit
Measures expressed ProLabel™ tagged
protein
93-0053

How does the assay work?

Click here to view assay principle of PCSK9
Click here to view assay principle of ADAM10

 

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