In this issue:

• Recent Developments
• Special Offers
• Presentations and Publications
• Announcements and Conferences
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Recent Developments - PathHunter™ Assays:

Directly Measure Gi, Gs, or Gq GPCR Activation in Single-addition Assays. PathHunter ß-Arrestin Assays are revolutionary high-throughput screening assays for monitoring GPCR activation following ligand stimulation without an imaging instrument, fluorescent protein tag, or radioactivity. Instead, the assays detect GPCR activation through ß-Arrestin binding to the expressed GPCR of interest, measuring the interaction of the two proteins using enzyme fragment complementation. The single-addition chemiluminescent detection protocol makes the assays ideal for microplate formats.

In addition to providing custom PathHunter™ ß-Arrestin services, DiscoveRx now offers over 30 qualified PathHunter GPCR ß-Arrestin Cell Pools expressing the following GPCRs:

For more information, please download a poster presented at SBS 06 or request a seminar or on-site demonstration.

Development of a non-imaging, homogeneous assay format for analysis of arrestin recruitment as a detection method for generic GPCR screening

Recent Developments - Kinase Assays:

NEW!! ADP Quest™ HS is now available! ADP Quest HS extends the applicability of our ADP assay kits to low levels of ADP detection (200nM to 25uM). ADP Quest HS is ideal for profiling low activity kinases or weak kinase inhibitors, or in cases where you may want to use a low concentration of ATP. ADP Quest HS is the ONLY commercial assay that allows you to profile kinase inhibitors in a kinetic assay with constant [ATP].

Special Offers:

Purchase a PathHunter™ ß-Arrestin cell pool or clonal cell line and receive detection reagents FREE. Please contact us at info@discoverx.com for details. Offer ends Dec. 15th, 2006.

ADP Quest HS - Buy two get 1 FREE! Please contact us at info@discoverx.com for details. Offer ends Dec. 15th, 2006.

New Publications of DiscoveRx Technology:

Enzyme fragment complementation binding assay for p38alpha mitogen-activated protein kinase to study the binding kinetics of enzyme inhibitors, Organon.  Assay Drug Dev Technol. 2006 Aug;4(4):411-20

American Society for Cell Biology
Booth #304
San Diego, CA
Dec 9-13, 2006

DiscoveRx – Simple Solutions for Complex Biology